latest news
(July 2008)
The ASTIS Trial (Autologous Stem cell Transplantation International Scleroderma Trial) is an international multicenter and investigator-driven trial conducted under the auspices of the European organization for Bone Marrow Transplantation (EBMT) and European League Against Rheumatism (EULAR). The protocol of the ASTIS Trial has been approved by Ethics Committees in centers from Austria, Canada, France, Germany, Greece, Italy, The Netherlands, Switzerland, and United Kingdom (see participating centres).
Our Study Administration Office has recently moved to the James Cook University Hospital, Middlesbrough, UK.
As of June 29 2008 122 patients have been randomized in 25 centres from 10 countries and allocated to either high dose immunoablation followed by autologous stem cell transplantation (66 patients) or pulse-therapy cyclophosphamide i.v (56 patients). All patients were enrolled because of severe systemic sclerosis with extensive skin thickening and involvement of heart, lung or kidneys.
A total of 150 patients will be enrolled into the study. If you have
any queries, please contact any of the study-chairpersons or the study
administration office based in James Cook University Hospital,
Middlesbrough, UK. Tel: (44) 1642 282498 Fax: (44) 1642 282861.
Kind
regards,
Jaap van Laar Dominique Farge Alan Tyndall
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Last change: 11 July 2008